| Identification | More | [Name]
FMOC-L-Isoleucine | [CAS]
71989-23-6 | [Synonyms]
2-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-3-METHYLPENTANOIC ACID
9-FLUORENYLMETHOXYCARBONYL-L-ISOLEUCINE
FMOC-ILE
FMOC-ILE-OH
FMOC-ISOLEUCINE
FMOC-L-ILE
FMOC-L-ILE-OH
FMOC-L-ISOLEUCINE
N-(9-FLUORENYLMETHOXYCARBONYL)-L-ISOLEUCINE
N-9-FLUORENYLMETHYLOXYCARBONYL-L-ISOLEUCINE
N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-ISOLEUCINE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ISOLEUCINE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ISOLEUCINE
N-ALPHA-FMOC-L-ISOLEUCINE
N-FMOC-ILE-OH
N-FMOC-L-ILE
N-FMOC-L-ISOLEUCINE
Fmoc-lle-OH
L-Isoleucine, FMOC protected
N-FMOC-ILE-OH ( N-FMOC-L-ISOLEUCINE) | [EINECS(EC#)]
276-255-9 | [Molecular Formula]
C21H23NO4 | [MDL Number]
MFCD00037125 | [Molecular Weight]
353.41 | [MOL File]
71989-23-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white fine crystalline powder | [Melting point ]
145-147 °C(lit.)
| [alpha ]
-12 º (c=1,DMF) | [Boiling point ]
486.83°C (rough estimate) | [density ]
1.2107 (rough estimate) | [refractive index ]
-12 ° (C=1, DMF) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in methanol (very faint turbidity). | [form ]
Fine Crystalline Powder | [pka]
3.92±0.22(Predicted) | [color ]
White | [Optical Rotation]
[α]20/D 12±1°, c = 1% in DMF | [Detection Methods]
T,NMR,HPLC,Rotation | [BRN ]
4716717 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/t13-,19-/m0/s1 | [InChIKey]
QXVFEIPAZSXRGM-DJJJIMSYSA-N | [SMILES]
C(O)(=O)[C@H]([C@@H](C)CC)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | [CAS DataBase Reference]
71989-23-6(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Synthesis]
Dissolve 1.05 g (0.008 mol) of L-isoleucine solid in a 10% sodium carbonate solution, stirring until the L-isoleucine solid is fully dissolved. At 20–30 °C, add dropwise a solution of 2.10 g (0.008 mol) of di-9-fluorenemethyloxycarbonyl chloride dissolved in toluene (2–205 mL). Add 3 drops of... Addition was carried out over 0–60 minutes, followed by stirring at 20–30°C for 1–8 hours. The mixture was then diluted with 30–200 mL of water and extracted with 80 mL of n-butyl acetate to remove excess 9-fluorenemethyloxycarbonyl chloride. The resulting aqueous phase was acidified with concentrated hydrochloric acid to pH 0.5–3.5, and then extracted with 80 mL of n-butyl acetate. The resulting oil phase was washed with water to remove hydrochloric acid, concentrated to remove the n-butyl acetate solvent, and white crystals precipitated. The crystals were filtered and dried to obtain 2.48 g of Fmoc-Ile-OH, with a yield of 87.9% and a melting point of 145–146°C. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [REACH Registrations]
Active | [HS Code ]
29242990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Description]
Fmoc-Ile-OH is an isoleucine derivative. It is white fine crystalline powder and belong to Fmoc materials. Fmoc-Leu-OH forms flower-like morphology at both low and high concentration under room temperature which changes to small tube-like structure on heating[1].
| [Chemical Properties]
white fine crystalline powder | [Uses]
N-Fmoc-L-isoleucine is an unnatural amino acid used for peptidomimetics. It is also used as a pharmaceutical intermediate. | [General Description]
The product number for this product was previously 04-12-1024.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis | [References]
[1] N. Gour, B. Koshti, S. Naskar, V. Kshtriya, H. Narode, Self-assembled Structures Formed by Fmoc modified aliphatic amino acids, ChemRxiv, 2021. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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